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Synthesis 1987; 1987(5): 523-524
DOI: 10.1055/s-1987-27993
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Synthesis of N-Acetyl-1,2-didehydrodopamine. A Key Intermediate Involved in Sclerotization of Insect Cuticle

B. Ramamurthy* , M. Sugumaran
  • *Department of Biology, University of Massachusetts at Boston, Harbor Campus, Boston, MA 02125, U.S.A.
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Publication Date:
18 September 2002 (online)

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The synthesis of N-acetyl-1,2-didehydrodopamine (6; N-acetyl-3,4-dihydroxystyrylamine) was accomplished by demethylation of N-acetyl-3,4-dimethoxystyrylamine (5), formed by sequential treatment of 3,4-dimethoxycinnamic acid (1) with thionyl chloride, sodium azide, heat and methyl magnesium bromide.